Generalized Myasthenia Gravis

《英文msh詞典》Generalized Myasthenia Gravis
[入口詞] Generalized Myasthenia Gravis
[主題詞] Myasthenia Gravis
[英文釋義] A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION,impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia,ptosis,and weakness of facial,bulbar,respiratory,and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al.,Principles of Neurology,6th ed,p1459)